No level of alcohol consumption is safe for our health. The WHO

4 January 2023 

News release

Reading time: 3 min (759 words)

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The risks and harms associated with drinking alcohol have been systematically evaluated over the years and are well documented. The World Health Organization has now published a statement in The Lancet Public Health: when it comes to alcohol consumption, there is no safe amount that does not affect health.

It is the alcohol that causes harm, not the beverage

Alcohol is a toxic, psychoactive, and dependence-producing substance and has been classified as a Group 1 carcinogen by the International Agency for Research on Cancer decades ago – this is the highest risk group, which also includes asbestos, radiation and tobacco. Alcohol causes at least seven types of cancer, including the most common cancer types, such as bowel cancer and female breast cancer. Ethanol (alcohol) causes cancer through biological mechanisms as the compound breaks down in the body, which means that any beverage containing alcohol, regardless of its price and quality, poses a risk of developing cancer.

The risk of developing cancer increases substantially the more alcohol is consumed. However, latest available data indicate that half of all alcohol-attributable cancers in the WHO European Region are caused by “light” and “moderate” alcohol consumption – less than 1.5 litres of wine or less than 3.5 litres of beer or less than 450 millilitres of spirits per week. This drinking pattern is responsible for the majority of alcohol-attributable breast cancers in women, with the highest burden observed in countries of the European Union (EU). In the EU, cancer is the leading cause of death – with a steadily increasing incidence rate – and the majority of all alcohol-attributable deaths are due to different types of cancers.

Risks start from the first drop

To identify a “safe” level of alcohol consumption, valid scientific evidence would need to demonstrate that at and below a certain level, there is no risk of illness or injury associated with alcohol consumption. The new WHO statement clarifies: currently available evidence cannot indicate the existence of a threshold at which the carcinogenic effects of alcohol “switch on” and start to manifest in the human body.

Moreover, there are no studies that would demonstrate that the potential beneficial effects of light and moderate drinking on cardiovascular diseases and type 2 diabetes outweigh the cancer risk associated with these same levels of alcohol consumption for individual consumers.

“We cannot talk about a so-called safe level of alcohol use. It doesn’t matter how much you drink – the risk to the drinker’s health starts from the first drop of any alcoholic beverage. The only thing that we can say for sure is that the more you drink, the more harmful it is – or, in other words, the less you drink, the safer it is,” explains Dr Carina Ferreira-Borges, acting Unit Lead for Noncommunicable Disease Management and Regional Advisor for Alcohol and Illicit Drugs in the WHO Regional Office for Europe. 

Despite this, the question of beneficial effects of alcohol has been a contentious issue in research for years.

“Potential protective effects of alcohol consumption, suggested by some studies, are tightly connected with the comparison groups chosen and the statistical methods used, and may not consider other relevant factors”, clarifies Dr Jürgen Rehm, member of the WHO Regional Director for Europe’s Advisory Council for Noncommunicable Diseases and Senior Scientist at the Institute for Mental Health Policy Research and the Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Canada.

We are missing the bigger picture

Globally, the WHO European Region has the highest alcohol consumption level and the highest proportion of drinkers in the population. Here, over 200 million people in the Region are at risk of developing alcohol-attributable cancer.

Disadvantaged and vulnerable populations have higher rates of alcohol-related death and hospitalization, as harms from a given amount and pattern of drinking are higher for poorer drinkers and their families than for richer drinkers in any given society.

“So, when we talk about possible so-called safer levels of alcohol consumption or about its protective effects, we are ignoring the bigger picture of alcohol harm in our Region and the world. Although it is well established that alcohol can cause cancer, this fact is still not widely known to the public in most countries. We need cancer-related health information messages on labels of alcoholic beverages, following the example of tobacco products; we need empowered and trained health professionals who would feel comfortable to inform their patients about alcohol and cancer risk; and we need overall wide awareness of this topic in countries and communities,” adds Dr Ferreira-Borges.

AVOID ALCOHOL 🤢🤮 when you’re pregnant @ClevelandClinic

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When you’re pregnant, it’s important to eat a healthy diet that provides the nutrients you need. That helps keep you feeling your best and promotes healthy fetal development. But pregnancy also puts you at higher risk for foodborne illness. Some foods and drinks can increase your risk for pregnancy complications. Avoid high-mercury fish and processed meat, and go easy on salt and caffeine.

Acetaldehyde, a toxic chemical produced when alcohol is metabolized in the body, has been linked to cancer risk…@AlcoholCancerEU

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In every political party, it’s likely that there is a doctor and a scientist. These professionals should take responsibility for explaining the science behind the link between alcohol and cancer.

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AlcoholAndCancer

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To minimize the risk of cancer, it’s recommended to limit alcohol consumption or avoid it altogether. #AlcoholAndCancer

Why is Alcohol so toxic for our body? 🍺🤔@drjeremylondon

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Dr.Paddy Barrett – The Truth About Alcohol and Health

Why the idea that “a little red wine is good for your heart” doesn’t hold up anymore.

I used to drink.

A lot more than I should have.

And while I had some seriously good times when I was drinking, it came at a huge cost.

Brutal hangovers. Terrible sleep. Wrecked weekends.

Even a broken back.

(But that’s a story for another day.)

I still drink.

But just very little these days.

As a cardiologist, I am asked almost every day if ‘Alcohol is good or bad for your health?’.

Let’s find out.

Alcohol Is A Toxin.

There is no getting away from the fact that, at its most basic chemical foundation, alcohol is a toxin.

Globally, alcohol is responsible for 3 million deaths per year; in the United States, it is the third leading cause of preventable death¹².

Alcohol is a factor in³:

  • 30% of suicides
  • 40% of fatal burn injuries
  • 50% of fatal drownings
  • 50% of homicides
  • 65% of fatal falls
  • 29% of fatal road traffic accidents

Alcohol is a factor in 1 in 5 emergency department presentations⁴.

No pun intended, but these statistics make for some sober reading.

‘Red Wine Is Good For Your Heart.’

Now come on.

Did you really think that was true?

I have heard this phrase over and over again in my clinical practice.

High levels of exercise are good for your heart, but oddly enough, most people seem to be far less enthusiastic about this approach than regular alcohol consumption.

Let’s see what the data says.

Up until very recently, it was believed that drinking 1-2 drinks per day was actually protective when it came to dying prematurely⁵.

This data was based on observational studies that cannot fully control for all confounders and can therefore not infer causality.

When you examine the people who drink only 1 to 2 drinks per day, you consistently find that they are much less likely to smoke, be overweight or engage in any other risky health behaviours.

So in truth, it probably wasn’t the alcohol that was driving the effect.

More recent studies have attempted to control for this variable more carefully, and the relationship is clear.

The more you drink.

The higher the risk.

Take coronary artery disease. Higher alcohol intake equates to a higher risk.

The same applies to high blood pressure⁶.

The same applies to stroke⁷.

The list goes on⁸:

  • Atrial fibrillation – Higher risk.
  • Sudden death – Higher risk.
  • Heart failure – Higher risk.
  • Liver, Breast, Colorectal, Oropharyngeal Cancer – Higher Risk⁹.

You get the point.

With all this information to hand, why is it then that I and billions of others continue to drink alcohol?…

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AVOID ALCOHOL 🤢🤮 when you’re pregnant @ClevelandClinic

Square profile picture

Cleveland Clinic

@ClevelandClinic

·

When you’re pregnant, it’s important to eat a healthy diet that provides the nutrients you need. That helps keep you feeling your best and promotes healthy fetal development. But pregnancy also puts you at higher risk for foodborne illness. Some foods and drinks can increase your risk for pregnancy complications. Avoid high-mercury fish and processed meat, and go easy on salt and caffeine.

Dr.Paddy Barrett – The Truth About Alcohol and Health

Why the idea that “a little red wine is good for your heart” doesn’t hold up anymore.

I used to drink.

A lot more than I should have.

And while I had some seriously good times when I was drinking, it came at a huge cost.

Brutal hangovers. Terrible sleep. Wrecked weekends.

Even a broken back.

(But that’s a story for another day.)

I still drink.

But just very little these days.

As a cardiologist, I am asked almost every day if ‘Alcohol is good or bad for your health?’.

Let’s find out.

Alcohol Is A Toxin.

There is no getting away from the fact that, at its most basic chemical foundation, alcohol is a toxin.

Globally, alcohol is responsible for 3 million deaths per year; in the United States, it is the third leading cause of preventable death¹².

Alcohol is a factor in³:

  • 30% of suicides
  • 40% of fatal burn injuries
  • 50% of fatal drownings
  • 50% of homicides
  • 65% of fatal falls
  • 29% of fatal road traffic accidents

Alcohol is a factor in 1 in 5 emergency department presentations⁴.

No pun intended, but these statistics make for some sober reading.

‘Red Wine Is Good For Your Heart.’

Now come on.

Did you really think that was true?

I have heard this phrase over and over again in my clinical practice.

High levels of exercise are good for your heart, but oddly enough, most people seem to be far less enthusiastic about this approach than regular alcohol consumption.

Let’s see what the data says.

Up until very recently, it was believed that drinking 1-2 drinks per day was actually protective when it came to dying prematurely⁵.

This data was based on observational studies that cannot fully control for all confounders and can therefore not infer causality.

When you examine the people who drink only 1 to 2 drinks per day, you consistently find that they are much less likely to smoke, be overweight or engage in any other risky health behaviours.

So in truth, it probably wasn’t the alcohol that was driving the effect.

More recent studies have attempted to control for this variable more carefully, and the relationship is clear.

The more you drink.

The higher the risk.

Take coronary artery disease. Higher alcohol intake equates to a higher risk.

The same applies to high blood pressure⁶.

The same applies to stroke⁷.

The list goes on⁸:

  • Atrial fibrillation – Higher risk.
  • Sudden death – Higher risk.
  • Heart failure – Higher risk.
  • Liver, Breast, Colorectal, Oropharyngeal Cancer – Higher Risk⁹.

You get the point.

With all this information to hand, why is it then that I and billions of others continue to drink alcohol?…

Subscribe to Dr Paddy Barrett to unlock the rest.

Become a paying subscriber of Dr Paddy Barrett to get access to this post and other subscriber-only content.

Upgrade to paid

A subscription gets you:

Subscriber Only Posts & Access To Full Archive
25% Discount On Live Education Sessions & AMA’s
Discounts On Courses & Live Education Sessions & AMA’s

Dr.Paddy Barrett – The Truth About Alcohol and Health

Why the idea that “a little red wine is good for your heart” doesn’t hold up anymore.

I used to drink.

A lot more than I should have.

And while I had some seriously good times when I was drinking, it came at a huge cost.

Brutal hangovers. Terrible sleep. Wrecked weekends.

Even a broken back.

(But that’s a story for another day.)

I still drink.

But just very little these days.

As a cardiologist, I am asked almost every day if ‘Alcohol is good or bad for your health?’.

Let’s find out.

Alcohol Is A Toxin.

There is no getting away from the fact that, at its most basic chemical foundation, alcohol is a toxin.

Globally, alcohol is responsible for 3 million deaths per year; in the United States, it is the third leading cause of preventable death¹².

Alcohol is a factor in³:

  • 30% of suicides
  • 40% of fatal burn injuries
  • 50% of fatal drownings
  • 50% of homicides
  • 65% of fatal falls
  • 29% of fatal road traffic accidents

Alcohol is a factor in 1 in 5 emergency department presentations⁴.

No pun intended, but these statistics make for some sober reading.

‘Red Wine Is Good For Your Heart.’

Now come on.

Did you really think that was true?

I have heard this phrase over and over again in my clinical practice.

High levels of exercise are good for your heart, but oddly enough, most people seem to be far less enthusiastic about this approach than regular alcohol consumption.

Let’s see what the data says.

Up until very recently, it was believed that drinking 1-2 drinks per day was actually protective when it came to dying prematurely⁵.

This data was based on observational studies that cannot fully control for all confounders and can therefore not infer causality.

When you examine the people who drink only 1 to 2 drinks per day, you consistently find that they are much less likely to smoke, be overweight or engage in any other risky health behaviours.

So in truth, it probably wasn’t the alcohol that was driving the effect.

More recent studies have attempted to control for this variable more carefully, and the relationship is clear.

The more you drink.

The higher the risk.

Take coronary artery disease. Higher alcohol intake equates to a higher risk.

The same applies to high blood pressure⁶.

The same applies to stroke⁷.

The list goes on⁸:

  • Atrial fibrillation – Higher risk.
  • Sudden death – Higher risk.
  • Heart failure – Higher risk.
  • Liver, Breast, Colorectal, Oropharyngeal Cancer – Higher Risk⁹.

You get the point.

With all this information to hand, why is it then that I and billions of others continue to drink alcohol?…

Subscribe to Dr Paddy Barrett to unlock the rest.

Become a paying subscriber of Dr Paddy Barrett to get access to this post and other subscriber-only content.

Upgrade to paid

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Alcohol has risks. We must all aim to minimise those risks. @DrPaddy_Barrett preventative cardiologist @HealthBlackrock

Let’s start with some simple facts.
Alcohol is a toxin.
Alcohol is a factor in1:
30% of suicides
40% of fatal burn injuries
50% of fatal drownings
50% of homicides
65% of fatal falls
29% of fatal road traffic accidents
Globally, alcohol is responsible for 3 million deaths per year; in the United States, it is the third leading cause of preventable death2 3.
It is hard to see the upside when you see these figures.
So let’s go a little deeper.
First off, I drink alcohol. Not a lot. But I do drink.
So any comments made here are not some puritanical position on alcohol but reflections on the data that exist in the literature.
Multiple studies have demonstrated that excess alcohol consumption, usually defined as consuming greater than 2 to 4 drinks per day, is associated with worse outcomes and a greater likelihood of dying when compared to someone who drinks less than 2 to 4 drinks per day4.

Alcohol Dosing and Total Mortality in Men and Women: An Updated Meta-analysis of 34 Prospective Studies. Arch Intern Med.2006

In the study shown above, females start to accrue an increased risk at greater than two drinks per day on average and males at greater than four drinks per day.

These findings shouldn’t come as a surprise to anyone.

Surprisingly, on average, individuals who consume less than two drinks per day appear to have better outcomes than those who do not drink at all. This is where things start to get a little counterintuitive, and the story of alcohol being beneficial for you starts to appear.

This relationship is known as a ‘U’ shaped curve where those in the middle have the best outcomes, and those on the edges have worse outcomes. A kind of ‘Goldilocks’ relationship; “Not too hot. Not too cold. Just right.”

How might we explain this?

Enter the darling of the 1990s, Resveratrol. This compound in red wine spawned the mantra that red wine was ‘good for your heart’. This was based on research that suggested that it might reduce cholesterol levels, among other things.

But to consume the levels of Resveratrol tested in some of the animal studies that demonstrated benefit, you would have to drink 40 litres of wine…… Per day.

Not exactly a feasible strategy. Even with the best will in the world.

Let’s look at a more plausible explanation.

Data on alcohol consumption and outcomes are almost always based on observational data, not randomised controlled trials. This means that other factors or ‘confounders’ may explain the difference between the groups, not the alcohol consumption alone.

When you look at the trials that suggest a benefit of modest alcohol consumption, you will often find that this group tend to exercise more, smoke less, be in a higher socioeconomic bracket etc. This is referred to as a ‘healthy user bias’ and is likely to explain the difference between the groups.

Most trials try to correct or adjust for these confounders, but in truth, it is very hard to do. A recent publication looked at this problem and attempted to (as much as possible) correct for these ‘healthy user’ bias factors and then compare outcomes between alcohol consumption groups. The results were a little more in line with what we might expect.

Those in the lowest alcohol consumption category had the best lifestyle factors overall. When these healthy factors were corrected for, any benefit seen with modest alcohol consumption disappeared. What remained was a linear relationship between alcohol consumption and coronary artery disease5. Much more what you might expect.

Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA Netw Open. 2022

Research like this and other studies is where the more recent media reports of ‘any’ alcohol being bad for you have come.

So, alcohol is a toxin. But, as Paracelsus notes:

“The dose makes the poison.”

Even water consumed to excess can be lethal.

We know that excess alcohol consumption is harmful. But I don’t think there was any great uncertainty around that point.

The key takeaway is that modest alcohol consumption is unlikely to be ‘beneficial’ to you. As much as you loved the idea that red wine was good for your heart, we can say with reasonable confidence that this is not the case.

The real question we need to answer is whether consuming modest amounts of alcohol is considerably worse for you when it comes to heart disease and death from any cause.

Based on the literature to date, it seems that the incremental risk for modest amounts of weekly alcohol consumption is likely to be small. But that doesn’t mean there are no downsides.

Sleep

One of the main reasons I significantly reduced my alcohol consumption was its effect on my sleep. If I drink more than one drink, I find that the quality of my sleep gets worse. I am much more likely to wake in the middle of the night and feel the effects the following day. But that’s just my personal experience.

Although alcohol is likely to make you fall asleep faster, it impacts your sleep quality6. Additionally, alcohol also reduces the percentage of REM sleep a person gets overnight7.

A workaround for me is to consume any alcohol during the daytime, so my sleep is unlikely to be affected, and if I am going to have a drink, I make sure it is worthwhile. I.e. I am with friends, or it is a high-quality drink. No more drinks on airplanes for me. Mainly because you lose about 30% of your sense of smell and taste in a pressurised cabin and therefore you are less likely to enjoy your drink8. Why do you think they serve you tomato juice and the fact that you think it’s tolerable?!

Humans have been consuming alcohol as far back as the ancient Egyptians, and some evidence suggests the Chinese were consuming alcohol as far back as 7000 B.C. So I don’t see alcohol disappearing any time soon.

The question we all need to ask is:

How much are we realistically drinking on a daily or weekly basis &

Is it likely to be doing us harm?

Only you can answer that question.

The only way to be certain you are doing no harm is to eliminate alcohol entirely. But life is full of risks, some of which we can control, some we cannot.

And some risks are worth taking.

Want to eliminate all road traffic accidents worldwide?

Simple.

Ban cars.

But at what cost?

The risks of driving are a risk most of us are willing to take.

Alcohol has risks.

We must all aim to minimise those risks.

Whatever that means for you, only you can decide.

1

https://www.rethinkingdrinking.niaaa.nih.gov/How-much-is-too-much/Whats-the-harm/What-Are-The-Consequences.aspx

2

Mokdad, A.H.; Marks, J.S.; Stroup, D.F.; and Gerberding, J.L. Actual causes of death in the United States, 2000. JAMA 291(10):1238–1245, 2004. Erratum in JAMA 293(3):298, 2005.

3

Centers for Disease Control and Prevention (CDC). Alcohol and Public Health: Alcohol-Related Disease Impact (ARDI). Annual Average for United States 2011–2015 Alcohol-Attributable Deaths Due to Excessive Alcohol Use, All Ages.

4

Alcohol Dosing and Total Mortality in Men and Women: An Updated Meta-analysis of 34 Prospective Studies. Arch Intern Med.2006;166(22):2437–2445. doi:10.1001/archinte.166.22.2437

5

Biddinger KJ, Emdin CA, Haas ME, et al. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA Netw Open. 2022;5(3):e223849. doi:10.1001/jamanetworkopen.2022.3849

6

Britton, A., Fat, L.N. & Neligan, A. The association between alcohol consumption and sleep disorders among older people in the general population. Sci Rep 10, 5275 (2020). https://doi.org/10.1038/s41598-020-62227-0

7

Ebrahim IO, Shapiro CM, Williams AJ, Fenwick PB. Alcohol and sleep I: effects on normal sleep. Alcohol Clin Exp Res. 2013 Apr;37(4):539-49. doi: 10.1111/acer.12006.

8

Burdack-Freitag, Andrea & Bullinger, Dino & Mayer, Florian & Breuer, Klaus. (2010). Odor and taste perception at normal and low atmospheric pressure in a simulated aircraft cabin. Journal für Verbraucherschutz und Lebensmittelsicherheit. 6. 95-109. 10.1007/s00003-010-0630-y.

Why is Alcohol so toxic for our body? 🍺🤔@drjeremylondon

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