Even casual drinking can put your long-term health at risk. Our liver specialist explains the findings of this study.
New Study: No Level of Alcohol — Even Casual Drinking — Is Entirely Safe
Leading cause of death of those age 15-49
Stopping for happy hour with colleagues after work. Cracking open a cold beer (or two) while watching the game. Meeting up with girlfriends for a glass of pinot noir. Having an alcoholic beverage of choice is a common way to unwind. But according to a recent study, even casual drinking can put your long-term health at risk.
Liver specialist Jamile Wakim-Fleming, MD, did not take part in the study, but says the research found that alcohol was a leading risk factor for both disease and premature death.
“They found that alcohol was the seventh leading cause of death worldwide,” she says. “But even more alarming, is that it was the first leading cause of death of people between the ages of 15-49.”
What the study examined
The study looked at global data from hundreds of previous studies and found that for all ages, alcohol was associated with 2.8 million deaths each year.
Researchers found that alcohol-related cancer and heart disease, infectious diseases, intentional injury, traffic accidents and accidental injury were some of the leading causes of alcohol-related deaths.
But isn’t alcohol good for your heart?
Dr. Wakim-Fleming says people often believe that a little bit of alcohol, wine in particular, may be good for their heart. But the study results didn’t show any health benefit to drinking any amount of alcohol.
She says this information, along with previous research that has shown more young people are dying from alcohol-related liver disease, indicates that excessive drinking among young adults is a growing problem.
The damage grows over time
And like any substance-abuse problem, Dr. Wakim-Fleming says the damage to the body from alcohol increases over your lifespan.
“It’s a cumulative effect,” she explains. “If you do it all at once, then you’re going to have the effect now. If you drink on a regular basis, over years it’s going to be cumulative and you will end up with a problem later on.”
Dr. Wakim-Fleming notes that anything we do in life involves risk, but it’s important to know what the risks are so that we can make the best decisions for our health.
A new Advisory on Alcohol and Cancer Risk outlines a connection between drinking alcohol and increased risk of cancer, specifically cancers of the mouth, throat, voice box, esophagus, breast, liver and colon.
When you wake up with a hangover, it’s a no-brainer that last night’s drinks didn’t do you much good. But research shows that the effects of heavy alcohol consumption may be doing much more to your body than just leaving you with one day of misery. Over time, as the drinks add up, alcohol can affect your biology, changing it in detrimental ways.
Excess alcohol consumption can:
1. Change Your DNA — and Make You Crave More Alcohol
Binge drinking, which the National Institute on Alcohol Abuse and Alcoholism (NIAAA) characterizes as more than four or five drinks in a two-hour sitting, and heavy drinking, defined as binge drinking on five or more days a month, can actually change your genetic makeup. A recent study, published in December 2018 in the journal Alcoholism: Clinical & Experimental Research, identified two genes that are subject to change — one affecting the body’s biological clock and one regulating the stress response system. The study’s authors, from Rutgers University, also found that the genetic changes in binge and heavy drinkers were associated with a higher desire for alcohol.
2. Increase the Risk of Cancer — Especially of the Head, Neck, Liver, and Breast
The National Cancer Institute (NCI) cites several studies, such as one published in August 2012 in the journal Annals of Oncology, that have shown consuming alcohol ups the risk of an array of cancers. In 2012, over 5 percent of all new cancer occurrences and nearly 6 percent of all cancer deaths worldwide were estimated to be attributed to alcohol, according to a study published in October 2015 in the International Journal of Cancer. In heavy drinkers, the risk skyrockets. For example, heavy drinkers are 5 times more likely than nondrinkers to contract esophageal cancer, according to the NCI. But even moderate drinking increases the odds of getting cancer of the mouth, throat, and breast. Kathy Jung, PhD, director of the NIAAA’s division of metabolism and health effects, cautions about breast cancer specifically, saying as little as one drink a day can increase risk.
3. Change the Composition of Organisms in the Gut
There are tens of trillions of microorganisms — mostly “good” bacteria — in the digestive tract that help the body do things like digest food and produce vitamins. But alcohol interferes with their composition and function, according to a study published in 2015 in the journal Alcohol Research: Current Reviews, which found that chronic alcohol consumption can cause bacterial overgrowth and imbalances in the intestine. This can result in a slew of digestive issues, including stomach pain, bloating, constipation, diarrhea, and rosacea.
4. Affect Long-Term Memory and Brain Structure
One night of binge or heavy drinking can lead to blackouts, spans of time from which the intoxicated person can’t remember key events and details — if they can remember anything at all. But alcohol consumption can also cause long-term problems with brain function. People who drink heavily, over a long period of time, are at risk of changing the brain’s “hard wiring,” which can lead to cognitive problems even after sobriety is attained, reports American Addiction Centers. Heavy alcohol consumption can also erode brain tissue and raise the risk of stroke, according to previous research.
5. Cause Hormonal Disturbances
Chronic heavy drinking can also wreak havoc on the body’s endocrine system. The hormone producing glands tap into several important functions of the body, including growth and development, metabolism, and mood. Research published in September 2013 in the journal Endocrine and Metabolism Clinics of North America found that drinking heavily, and often, can disrupt communication between the nervous, endocrine, and immune systems. The consequences can be serious and wide ranging. Stress abnormalities, reproductive deficits, body growth defects, and immune dysfunction are just a few of the possible outcomes topping the list.
How Much Alcohol Is Too Much?
Medical professionals advise moderation when it comes to alcohol consumption. More than one drink a day for women and two for men gets into heavy and binge drinking territory, according to dietary guidelines published by the federal government’s Office of Disease Prevention and Health Promotion.
“Having one drink every day of the week is not the same as having seven drinks on a Saturday,” Dr. Jung says. “Binge drinking is never safe.”
What Does Alcohol Do to Your Body? 9 Ways Alcohol Affects Your Health
Alcohol affects your whole body, from your liver and immune system to your brain and mental health
You probably already know that excessive drinking can affect you in more ways than one.
There are the empty calories that can lead to weight gain. There’s the potential for injury and regrettable choices. And don’t forget about the hangovers of course.
Heavy drinking can also lead to a host of health concerns, like brain damage, heart disease, cirrhosis of the liver and even certain kinds of cancer.
And that’s on top of the toll that alcohol use can take on relationships, not to mention the potential for financial strain and legal troubles.
But even moderate alcohol use changes the way your body functions.
We talked with hepatologist Shreya Sengupta, MD, about how alcohol use affects your body and your emotional health.
“Some people think of the effects of alcohol as only something to be worried about if you’re living with alcohol use disorder, which was formerly called alcoholism,” Dr. Sengupta says.
“But when you consider how alcohol is metabolized and used by your body, we can start to see that even moderate and social drinking affects our health to some degree.”
Dr. Sengupta shares some of the not-so-obvious effects that alcohol has on your body.
Liver
Your liver detoxifies and removes alcohol from your blood through a process known as oxidation. When your liver finishes that process, alcohol gets turned into water and carbon dioxide.
But when you ingest too much alcohol for your liver to process in a timely manner, a buildup of toxic substances begins to take a toll on your liver.
If alcohol continues to accumulate in your system, it can destroy cells and, eventually, damage your organs.
“When your liver is overwhelmed by oxidizing alcohol, it generates molecules that inhibit fat oxidation,” Dr. Sengupta explains. “The fats build up. Over time, it can lead to a condition known as steatotic liver disease.”
Steatotic liver disease used to go by the name fatty liver disease.
Steatotic liver disease develops in about 90% of people who drink more than 1.5 to 2 ounces of alcohol per day. That’s about one shot glass worth.
With continued alcohol use, steatotic liver disease can lead to liver fibrosis. Eventually, you can develop permanent and irreversible scarring in your liver, which is called cirrhosis.
“The good news is that earlier stages of steatotic liver disease are usually completely reversible in about four to six weeks if you abstain from drinking alcohol,” Dr. Sengupta assures.
Cirrhosis, on the other hand, is irreversible and can lead to liver failure and liver cancer, even if you abstain from alcohol.
Metabolism
You probably are keenly aware of the so-called “beer belly.” That’s shorthand for a round midsection that some people associate with drinking too much beer.
In reality, there’s no evidence that drinking beer (or your alcoholic beverages of choice) actually contributes to belly fat.
But there’s plenty of research to back up the notion that alcohol does lead to weight gain in general. Even for people who aren’t particularly heavy drinkers.
“Drinking gives your body work to do that keeps it from going about its other processes,” Dr. Sengupta notes. “Alcohol distracts your system from its regularly scheduled duties, including things like metabolizing carbohydrates and fats.”
Once you take a drink, your body makes metabolizing alcohol a priority — above processing anything else.
That’s because your body already has processes in place that allow it to store excess proteins, carbohydrates and fats. But there isn’t a storage tank for alcohol. So, your system prioritizes getting rid of alcohol before it can turn its attention to its other work.
That allows excess calories from the foods you eat to sit around, leading to weight gain.
Gut health
Your gut microbiome is a hotbed of bacteria that help keep your digestive system happy and healthy. The trillions of microbes in your colon and large and small intestines are critical to proper digestion. They also help fend off inflammation and support healthy metabolism.
When you drink too much alcohol, it can throw off the balance of good and bad bacteria in your gut.
“Alcohol can kill the good bacteria that live in your gut, allowing bad bacteria to grow unchecked,” Dr. Sengupta explains. “That can lead to problems with digestion, inflammation and even organ damage.”
Having a glass of wine with dinner or a beer at a party here and there isn’t going to destroy your gut. But even low amounts of daily drinking and prolonged and heavy use of alcohol can lead to significant problems for your digestive system.
There are a few studies that associate red wine with improved heart health in lab tests. But no research proves that red wine causes any improvements in heart health in people.
“The reality is that alcohol causes more health troubles than it could ever help,” Dr. Sengupta reinforces. “And that goes for your heart, as well as the rest of your body.”
Pancreas
Your pancreas helps your body digest food and manage your blood sugar. Drinking alcohol changes how your pancreas works.
“Your pancreas secretes fluids. Alcohol use can thicken those fluids, which can clog the ducts that those fluids flow out of,” Dr. Sengupta explains.
Like a clog in a drain, those thickened fluids can jam up your ducts. That can lead to pancreatitis, which is inflammation of the pancreas.
Pancreatitis can be a short-term (acute) condition that clears up in a few days. But prolonged alcohol abuse can lead to chronic (long-term) pancreatitis, which can be severe.
Your body breaks alcohol down into a chemical called acetaldehyde, which damages your DNA. Damaged DNA can cause a cell to grow out of control, which results in cancerous tumors.
Alcohol use has been shown to raise your risk for several kinds of cancer. That includes cancers of the:
Mouth.
Esophagus.
Throat.
Liver.
Breast.
Colon and rectum.
Immune system
If you drink every day, or almost every day, you might notice that you catch colds, flu or other illnesses more frequently than people who don’t drink. That’s because alcohol can weaken your immune system and make your body more susceptible to infection.
“We see lower levels of a specific kind of white blood cells called lymphocytes in people who drink heavily for long periods of time,” Dr. Sengupta reports. “That can leave them more vulnerable to infectious diseases.”
Brain
The morning after a night of over-imbibing can cause some temporary effects on your brain. Things like trouble concentration, slow reflexes and sensitivity to bright lights and loud sounds are standard signs of a hangover, and evidence of alcohol’s effects on your brain.
Long-term alcohol use can change your brain’s wiring in much more significant ways. Ways that your standard hangover cures won’t even begin to touch.
“Excessive alcohol consumption can cause nerve damage and irreversible forms of dementia,” Dr. Sengupta warns.
Mental health
Alcohol is a depressant. And prolonged alcohol use can lead to mental health conditions like anxiety and depression. Chronic misuse can also lead to paranoia and hallucinations.
Even drinking a little too much (binge drinking) on occasion can set off a chain reaction that affects your well-being. Lowered inhibitions can lead to poor choices with lasting repercussions — like the end of a relationship, an accident or legal woes. Each of those consequences can cause turmoil that can negatively affect your long-term emotional health.
“Alcohol tends to cause more problems than it solves for a lot of people,” Dr. Sengupta emphasizes. “If drinking is affecting your health, your relationships, your work, your finances, it’s time to make some serious changes.”
If you need more guidance to quit drinking, the Substance Abuse and Mental Health Services Administration (SAMHSA) offers a hotline, 24/7, 365 days a year. Call 1.800.662.HELP (4357).
Alcoholics Anonymous is available almost everywhere and provides a place to openly and nonjudgmentally discuss alcohol issues with others who have alcohol use disorder.
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